However, the molecular profile and functional properties of iPSC‐PC under hypoxic conditions, similar to those found in ischemic and neurodegenerative diseases remain largely unexplored.Methods: We examined iPSC‐PC under hypoxia to assess molecular marker expression, proliferation, ability to home to brain vessels, and uptake of amyloid beta (Aβ).Results: iPSC‐PC under severe hypoxia retain essential functional properties, including key molecular markers, proliferation rates, and the ability to migrate to host brain vessels via function‐associated PDGFRB‐PDGF‐BB signaling. Here, PDGFRB is linked to neurodegenerative disease.