CLU and Global developmental delay: While Clu and Stromal 4 have both been observed in fetal gut (37, 50), we found a notably low expression of fetal distal colon progenitors (50), suggesting that the dynamic changes in ISCs in the distal colon of HSCR are not attributed to developmental delays but are instead highly reliant on microenvironmental changes that facilitate this fetal-like reprogramming.