However, a decreased expression of piR‐57 125 in ccRCC tissues has been observed, which is linked to the suppression of ccRCC metastasis through the direct targeting of CC chemokine 3 (CCL3) and the inhibition of the AKT/ERK pathway [38] (Figure 2C). The gene discussed is AKT1; the disease is nonpapillary renal cell carcinoma.