LPCAT3 and type 2 diabetes mellitus: S15 Table presents the results of an ROC curve analysis for predicting T2DM incidence based on serum LPCAT3 levels. The optimal cut-off point for LPCAT3 was determined to be 30.133 ng/ml, with a sensitivity of 42.19% (95% CI: 36.1–48.5) and a specificity of 71.83% (95% CI: 65.8–77.3). The Youden index at this cut-off point, calculated as Sensitivity + Specificity – 1, would be approximately 0.140. The area under the curve (AUC) was 0.580 (95%CI: 0.531–0.630, p < 0.01), indicating the overall discriminative ability of serum LPCAT3 levels in predicting T2DM incidence.