This finding lays the groundwork for innovativestrategies aimed at inhibiting the interaction between these entities,offering promising avenues for therapeutic intervention against COVID-19.We also estimated the binding free energy of DNA to Pol α-primase,SARS1 NSP1-Pol α-primase, and SARS2 NSP1-Pol α-primaseusing the MM-PBSA method. Here, SH2D3A is linked to COVID-19.