SH2D3A and COVID-19: Thisresponse triggers the secretion of type-I and type-III interferons,activating a signaling cascade that induces the expression of a diversearray of IFN-stimulated genes. In thecontext of COVID-19, a distinctive feature is the compromised IFNresponse in the host, accompanied by elevated levels of inflammatorycytokine production. SARSCoV-2 employsvarious mechanisms to dampen the innate immune response, involvingthe participation of several viral proteins such as NSP1, NSP6, NSP13,M, ORF3a, ORF6, and ORF7a/b.,