NR3C2 and hydrops fetalis: We aimed to study the trajectories of kidney function preceding and following HF-related events using individual patient data from two clinical trials: The Eplerenone Post Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS),10 and the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF),11 and ‘real world’ data from the BARCELONA cohort.12 Additionally, we assessed whether mineralocorticoid receptor antagonist (MRA) therapy influenced the association between change in kidney function and HF events.