Likewise, the set of terminal candidates includedthose important for mitochondrial homeostasis, function and gene expression(e.g., progesterone receptor membrane component 1 (PGRMC1), LYR motifcontaining 7 (LYRM7), and G-Rich RNA sequence binding factor 1 (GRSF1))or with roles in adipocyte differentiation and associations to obesity(lysophospholipase-like 1 (LYPLAL1); Figure I). The gene discussed is GRSF1; the disease is obesity due to melanocortin 4 receptor deficiency.