Given the opposing trajectories of neutrophils with T cells and MDCs over time, we first focused on outgoing signals from neutrophils to these cell types, finding that at d10 CoMtb increased costimulatory Cd80–Cd28 interactions with T cells, while primary infection was associated with increased Lgals9–Cd45 interactions with T cells and MDCs, which can be anti- or pro-inflammatory, depending on context, as well as likely inhibitory App–Cd74 interactions with MDCs (Fig. 3, C and D) (Liu and Stowell, 2023; Rabinovich and Toscano, 2009). The gene discussed is CD28; the disease is infection.