CD177 and Granuloma: These lesions possessed heterogeneous organization, with 15/27 of these single lesions presenting as granulomas containing a central necrotic core dominantly comprised of neutrophils (CD177-positive cells), necrotic debris (nuclear dye), and absence of alveolar epithelial staining (p120), consistent with destruction of the epithelial architecture (Fig. 1, D–F and Fig. S1 C).