For RNA sequencing, principal component analysis showed no close grouping of patient keratinocyte populations as expected from a diverse group of tumors, with respect to HPV status and anatomical location, HNSCC keratinocyte populations loosely clustered based on TGF‐β response, and levels of p‐EMT markers, primarily driven by principle component 1 (Figure 6A). The gene discussed is TGFB1; the disease is head and neck squamous cell carcinoma.