In this study, single‐cell transcriptome analysis revealed distinct subsets of APOE+ macrophages, and subsequent CellChat analyses highlighted that these cells predominantly interact with other components of the tumour microenvironment via MIF‐(CD74+CXCR4) and MIF‐(CD74+CD44) signalling pathways, thereby contributing to the establishment of an immunosuppressive milieu. The gene discussed is APOE; the disease is neoplasm.