MYCN and neuroblastoma: Most patients with amplified MYCN strongly expressed the protein.15 Nevertheless, MYCN protein overexpression can occur without oncogene amplification, and in these cases, the prognostic value remains controversial.26 Some studies have attempted to demonstrate the prognostic value of MYCN protein expression in NB.26,27 In a study involving 69 patients with INSS 3 and 4 with non-amplified genes, the level of MYCN expression was not predictive of outcomes.26 Conversely, more recent studies from the Children’s Oncology Group and those conducted in China showed conflicting results.