DCIS.com cells exhibit PI3K mutations that enhance AKT activity.52 In colon cancer, AKT/GSK3B stabilizes B-catenin and positively regulates CCR2 and MET activity.53,54 As such, PI3K mutations could indirectly affect CCL2 and HGF signaling in DCIS.com cells. This evidence concerns the gene MET and malignant colon neoplasm.