In metastatic tumors, pathway and TF analyses revealed strong hypoxia-inducible factor-1α–driven hypoxia activation, influencing glycolysis (SLC2A1, SLC2A3, PGK1, PDK1, PGM1, and ALDOA), angiogenesis (ANGPTL4 and ADM), and survival in low oxygen (BNIP3, BNIP3L, and NDRG1; Fig. 5E; Supplementary Fig. S7H). The gene discussed is PDK1; the disease is metastatic neoplasm.