However, the production of cathelicidin by colonic epithelium infected with C. rodentium could be crucial for direct antimicrobial defenses or other local signaling mechanisms, as the peptide is overexpressed in the epithelium during infections.82 Thus, cathelicidins may have compartmentalized functions, with immune cell-derived CRAMP activating ROS synthesis and influencing mucus secretion and other goblet cell proteins through distinct mechanisms compared to epithelial-derived CRAMP. The gene discussed is CAMP; the disease is infection.