Cross-sectional studies on liver cirrhosis demonstrate correlations between disease progression and alterations in the osteocyte lacunar network along with serum sclerostin levels, with disrupted osteocyte lacunar architecture and elevated serum sclerostin concentrations in cirrhotic patients (Rhee et al., 2014; Jadzic et al., 2022). Here, SOST is linked to cirrhosis of liver.