Conversely, TRIM21 deficiency enhances VDAC2 oligomerization-mediated cytosolic mtDNA release, activates the cGAS/STING cytosolic DNA sensing pathway, potentiates the antigen-presenting capacity of tumor cells, and activates cytotoxic T cell-mediated anti-tumor immunity in response to radiation (Li JY. The gene discussed is TRIM21; the disease is neoplasm.