Cardiovascular complications take the lead when diminished survival in CKD patients is assessed, with death being more frequent from cardiac conditions.15,16 This increased risk is fueled by a number of underlying mechanisms, such as chronic inflammation, calcium and phosphate imbalance regulation, oxidative stress, and the formation of vascular calcifications.17 B-type natriuretic peptide (BNP), a hormone secreted by the heart in response to elevated wall tension and pressure, is a biochemical marker of these hemodynamic alterations. The gene discussed is NPPB; the disease is chronic kidney disease.