NPPB and heart disorder: Miyakuni et al. and Wan et al. showed that levels of NT-proBNP are independently linked to higher cardiovascular mortality in patients with decreased Glomerular Filtration Rate (GFR), even without apparent cardiac disease.10,11 Other research, however, implies that BNP can offer greater diagnostic sensitivity in advanced CKD because it has a more direct representation of acute cardiac stress.12