Logistic regression analysis with urinary albumin as the dependent variable (with=1, none=0) and MCP-1, MIF, and ICAM-1 as independent variables showed that higher levels of MCP-1 (OR=1.040, 95% CI: 1.025-1.055, P<0.001), MIF (OR=1.013, 95% CI: 1.004-1.023, P=0.006) and ICAM-1 (OR=1.012, 95% CI: 1.006-1.019, P<0.001) were risk factors for DKD in T2DM (Table-II). The gene discussed is ICAM1; the disease is type 2 diabetes mellitus.