ROC curves which were done to explore the clinical predictive value of MCP-1, MIF, and ICAM-1 for DKD in T2DM showed that the AUC of MCP-1, MIF, and ICAM-1 for diagnosing DKD were 0.895 (95% CI: 0.857-0.933, P<0.001), 0.719 (95% CI: 0.653-0.785, P<0.001), and 0.827 (95% CI: 0.773-0.880, P<0.001), respectively. The gene discussed is CCL2; the disease is type 2 diabetes mellitus.