ICAM-1 is an acute phase protein marker of inflammation.11 The high expression of ICAM-1 on the surface of renal endothelial cells can lead to increased leukocyte adhesion, trigger local inflammatory reactions, and accelerate kidney damage.11 The clinical study by Siddiqui et al.23 showed that ICAM-1 levels indicate microvascular complications in T2DM patients. This evidence concerns the gene ICAM1 and type 2 diabetes mellitus.