ROC analysis demonstrated that the area under the curve (AUC) of MCP-1, MIF, and ICAM-1 for diagnosing DKD were 0.895 (95% CI: 0.857-0.933, P<0.001), 0.719 (95% CI: 0.653-0.785, P<0.001), and 0.827 (95% CI: 0.773-0.880, P<0.001), respectively. This evidence concerns the gene ICAM1 and diabetic kidney disease.