In the field of perinatal medicine, SGA infants may face many challenges in growth and development during the growth stage.9,10 The causes of SGA are complex and involve multiple factors, including maternal factors, placental and cord factors, genetic factors, fetal and environmental factors, and metabolic diseases.11-13 The age of 0 - 24 months is a critical period for catch-up growth in SGA infants, during which multifaceted therapeutic approaches mainly include appropriate nutritional and feeding interventions, growth hormone therapy, and neurological interventions.14-16. Here, GH1 is linked to metabolic disease.