The study explores the clinical manifestation of Atopic Dermatitis (AD), a condition marked by acute or chronic pruritic skin lesions on dry skin, whose pathogenesis is linked to skin barrier defects, complex immune dysregulation, and IgE-mediated factors.11 Patients with moderate to severe AD often experience a diminished quality of life, grappling with chronic rash, severe itching, sleep deprivation, dietary restrictions, and psychosocial impacts. The gene discussed is IGHE; the disease is Alzheimer disease.