For example, Ni et al. demonstrated that PI3K/AKT signaling can induce abnormal cell cycle changes and cell proliferation in the glomeruli by enhancing GLUT1-mediated glucose transport (Ni et al., 2022), and Xu et al. showed that inhibiting the PI3K/AKT pathway significantly impedes tumor growth and downregulates GLUT1 expression (Xu et al., 2020). This evidence concerns the gene SLC2A1 and neoplasm.