Its main clinical manifestations include: bicuspid aortic valve, patent ductus arteriosus, refractory epileptic seizures, intellectual disability, neuronal migration disorders, etc. Previous case reports have also found that a family with heritable PAH carried a novel heterozygous splicing mutation in the FLNA gene (Hirashiki et al., 2017). Here, FLNA is linked to Abnormality of neuronal migration.