Its main clinical manifestations include: bicuspid aortic valve, patent ductus arteriosus, refractory epileptic seizures, intellectual disability, neuronal migration disorders, etc. Previous case reports have also found that a family with heritable PAH carried a novel heterozygous splicing mutation in the FLNA gene (Hirashiki et al., 2017). The gene discussed is FLNA; the disease is Patent ductus arteriosus.