The expression of LDLR in the pancreas, leading to increased LDL-C concentration in the pancreas, induces the lipotoxic effect of β cells and β-cell dysfunction, impairs insulin secretion, and promotes the development of type 2 diabetes mellitus (Laakso and Fernandes Silva, 2023; Takei et al., 2020). The gene discussed is INS; the disease is type 2 diabetes mellitus.