Recent studies have shown that GDF-15 secreted by M2-polarized tumor-associated macrophages promotes ferroptosis resistance in AML cells by modulating the SLC7A11/GPX4 axis (Lu and Liao, 2025); however, this mechanism has not yet been validated in MM, and the roles of other immune cells within the TME remain unexplored. This evidence concerns the gene GPX4 and acute myeloid leukemia.