Then, the chi-square test was used to evaluate the correlations between EDEM1 expression and clinicopathologic features of breast cancer patients, including age, tumor stage, LN metastasis, distant metastasis, histologic grade, ER (estrogen receptor) status, PR (progesterone receptor) status, HER-2 status, and Ki67 expression. The gene discussed is ESR1; the disease is neoplasm.