Mechanistically, electroacupuncture combined with body acupuncture at cognition-targeted acupoints (e.g., GV20, DU24) is projected to outperform manual acupuncture or sham interventions, supported by evidence of enhanced cholinergic neurotransmission (elevated choline acetyltransferase activity) and reduced Alzheimer’s disease pathology. Here, CHAT is linked to early-onset autosomal dominant Alzheimer disease.