Meanwhile, aerobic exercise can increase the levels of P-AMPK and p-AMPK/AMPK in liver tissues of rats on high-fat diet, and activated adenosine monophosphate-activated protein kinase phosphorylation (AMPK) can effectively inhibit the key enzymes of lipid synthesis as well as the expression of SREBP-lc and FAS, which can effectively decrease fat synthesis and inhibit the accumulation of visceral fat, thus preventing and controlling MASLD (17, 18). This evidence concerns the gene FAS and metabolic dysfunction-associated steatotic liver disease.