A year later, Jia et al. [57] found that the expression of sEVs synaptic proteins, including neurogranin (NRGN), growth-associated protein 43 (GAP43), synaptotagmin 1, and synaptosome-associated protein 25 (SNAP25), was lower in AD patients than in healthy controls. This evidence concerns the gene NRGN and Alzheimer disease.