Hyperglycemia induced oxidative stress activates NFkB, a pro‐inflammatory cytokine that mediates the release of other pro‐inflammatory mediators (e.g., iNOS) and anti‐inflammatory cytokines (e.g., IL‐10) (Soufi et al. 2012; Iyer and Cheng 2012; Wu et al. 2016; Li et al. This evidence concerns the gene NOS2 and Hyperglycemia.