The highly significant negative correlation that was obtained between SOD versus VEGF (−0.828), GPx versus SOD (−0.818), GSH versus VEGF (−0.771), CAT versus SOD (−0.840), GST versus VEGF (−0.754), IL‐10 versus VEGF (−0.768), HDL versus VEGF (−0.769), Bcl versus VEGF (−0.785), HDL versus VEGF (−0.769) suggests that the supplements may have improved the pathological changes in the retina of the diabetic rats through improvement of retinal antioxidant activity as well as decreased dyslipidemia, retinal inflammation and apoptosis. This evidence concerns the gene SOD1 and metabolic syndrome.