MR results additionally implicated CFHR4, CFD, and MBL2 as causal proteins for AMD (Supplementary file: Table S6 and Figure 8A), while colocalization analysis identified C3, CD46, CFD, CFI, and MASP1 as potential contributors to the pathogenesis of AMD (Supplementary file: Table S7 and Figure 8B). This evidence concerns the gene CD46 and age-related macular degeneration.