C3 and age-related macular degeneration: In total, 79 independent genome-wide significant SNPs were identified across 41 well-established AMD loci (such as CFH, ARMS2, C3, and VEGFA), along with two novel index SNPs (rs1713998 and rs12913832) near or within NOA1 and OCA2, respectively, reaching genome-wide significance for the first time (p<5×10-8) (Supplementary file: Figure 1 and Table S2).