Histologically, NGOC is characterized by the presence of two distinct trophoblastic cell types: cytotrophoblasts, which form sheets resembling villus-like structures, and syncytiotrophoblasts, which localize at the invasive front of the tumor and are responsible for the secretion of β-hCG and human placental lactogen (hPL) [14]. The gene discussed is LGALS1; the disease is neoplasm.