MAPT and early-onset autosomal dominant Alzheimer disease: Predictive models that incorporate features from the entire functional connectome can help address these gaps, particularly because cross-validation21,22 procedures reduce in-sample inflation, which is critical for studies with potential clinical applications.23 Accordingly, we used predictive modelling to evaluate whether the functional connectome can predict amyloid-β and tau PET signal in preclinical Alzheimer’s disease.