Amyloid-β spreads quickly and diffusely throughout the neocortex, a process which can begin decades prior to symptom onset.1,2 In amnestic Alzheimer’s disease, tau spread parallels clinical symptomatology and occurs in a stereotyped manner, following Braak staging.3 Cortical tau build-up typically begins in the entorhinal cortex, then spreads to the medial and lateral temporal cortices and cingulate gyrus, corresponding with the first overt cognitive changes. The gene discussed is MAPT; the disease is Alzheimer disease.