This variability is further supported by recent work applying CPM to familial Alzheimer’s disease, which corroborates our finding that PreC tau can be predicted from FC.52 However, unlike our preclinical Alzheimer’s disease models, this study also found high predictability of entorhinal tau—a difference that may reflect the distinct disease trajectories between sporadic and genetic Alzheimer’s disease patients. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.