TNF and cancer: In the KEGG pathway enrichment analysis, the top 10 pathways associated with these targets were identified as: prostate cancer, endocrine resistance, transcriptional misregulation in cancer, renin-angiotensin system, TNF signaling pathway, estrogen signaling pathway, breast cancer, proteoglycans in cancer, diabetic cardiomyopathy, and lipid and atherosclerosis (Figure 6D).