GRM3 and Cognitive impairment: Although there has been little focus on postsynaptic mGluR3 regulation of Ca2+ signaling, perhaps due to its more limited role in rodents (Woo et al., 2022), GCPII inflammatory erosion of mGluR3 signaling appears to be a large contributor to cognitive impairment in both nonhuman and human primates (Wiseman et al., 2025; Yang et al., 2022; Zink et al., 2020).