Duan W et al (6) report the role of hyperglycemia on cancer proliferation, where-in proliferation assays reveal that high levels of glucose (11 Mmol/L) and insulin (100 ng/mL) have promoted the growth of following tumor cell lines: HT29 (human colon carcinoma), SW480 (human colorectal carcinoma), MCF-7 (human breast adenocarcinoma), MDA MB468 (human breast adenocarcinoma), PC3 (human prostate cancer), and T24 (human bladder carcinoma). This evidence concerns the gene INS and colorectal carcinoma.