MRPS22 and heart disorder: For example, decreased expression of the following proteins has been linked to the development of heart disease: mitochondrial ribosomal protein S3 (MRPS3), mitochondrial ribosomal protein S22 (MRPS22), mitochondrial ribosomal protein 10 (MRP10), and mitochondrial ribosomal protein S44 (MRPS44) (74, 75).