MRPS5 and hydrops fetalis: MRPS5 deficiency disrupts mitochondrial ultrastructure, impairs ATP production, and suppresses the expression of Krüppel-like factor 15 (KLF15) via the c-Myc-mediated signaling pathway, leading to metabolic dysregulation, myocardial hypertrophy, and HF (79) (Supplementary Table S1).