Mechanistically, changes in brain function may be related to insulin resistance and chronic inflammation; insulin not only regulates blood glucose, but also plays a role in the brain in regulating appetite and energy balance; insulin resistance may lead to disruption of insulin signaling pathways in the brain, which in turn affects the regulation of the desire to eat (Fordahl and Jones, 2017; Lyra et al., 2019). The gene discussed is INS; the disease is Insulin resistance.