TNF and obesity due to melanocortin 4 receptor deficiency: In this study, compared with the healthy population, there were significant abnormalities in DTI indexes in the orbitofrontal cortex brain region of patients with simple obesity, which could be supported by combining with the previous studies, and the FA value of the hook fascicle was negatively correlated with BMI, suggesting that the visceral fat accumulation may be caused by the release of pro-inflammatory factors (e.g., TNF-α, IL-6) to directly damage white matter fibers (Verstynen et al., 2013; García-García et al., 2022; Emanuela et al., 2012).