NF-κB is a key link between inflammation and tumorigenesis (Wei et al., 2023) by encoding pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 (Cuellar-Nunez et al., 2021, Medicherla et al., 2015), which promote DNA damage and transform colon cells into cancer cells (Zhang et al., 2023). This evidence concerns the gene TNF and cancer.