CML is a well-defined MPN driven by the BCR::ABL1 fusion gene, which results from a translocation between chromosome 9 (ABL1) and chromosome 22 (BCR), creating a constitutively active tyrosine kinase that drives uncontrolled myeloid proliferation [5]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.