IL17A and Netherton syndrome: Cai et al. suggested that even though retinoids can make a difference in Netherton syndrome by improving scaling and inflammation, they may have many side effects [49]. In contrast, Eichenfield et al. concluded that biologic treatments tackling Th2 and IL-17 pathways seem promising, and carefully managing the skin with regular treatments and infections is necessary because Netherton syndrome impairs the skin’s defenses [73].