Mechanical damage to the basal layer of the endometrium, commonly due to intrauterine surgeries (e.g., abortion, curettage) or infections (e.g., Mycobacterium tuberculosis, HPV), leads to exposure of vascular endothelial cells and the release of profibrotic factors such as TGF-β1 and platelet-derived growth factor (PDGF). The gene discussed is TGFB1; the disease is infection.