LGALS3 and congestive heart failure: For example, the study by Wijk et al. [15], which derived data from RCT subgroups (TIME-CHF and GISSI-HF), reported a significant interaction between Gal-3 levels and β-blocker efficacy, with low Gal-3 patients benefiting more from up-titration (HR: 2.42, p = 0.02).