None of the patients in our study required corrective scoliosis surgery in our institution; however, two out of four patients (50%) had surgery elsewhere (records not available), which is a higher percentage compared to surgical correction performed in other studies [26, 27]. The MECP2 mutations R255X and R168X have been associated with a higher incidence of scoliosis, while R133X is associated with a lower incidence [28]. Here, MECP2 is linked to scoliosis.