Additionally, white blood cell count (WBC) and hypersensitive C-reactive protein (hs-CRP) were significantly higher in the REM-OSA group than in the NREM-OSA group in the present study (p < 0.05), and these inflammatory factors may affect neuromodulation in the brain, thereby lowering the arousal threshold. The gene discussed is CRP; the disease is obstructive sleep apnea syndrome.