Analysis of the TCGA Liver Hepatocellular Carcinoma dataset (TCGA’s Pan-Cancer Atlas) revealed a low mutation and amplification frequency in HCC for SLCO1B1 (0.57% vs. 0.29%), SLCO1B3 (0.86% vs. 0.29%), and SLCO2B1 (0.57% vs. 0.86%), respectively. This evidence concerns the gene SLCO1B1 and hepatocellular carcinoma.