Preliminary studies in the mouse model reported that homozygous mutated ALMS1 females were prone to develop obesity, in turn responsible for a chronic anovulatory state and infertility (12); moreover, the alteration of the ALMS1 gene was associated with hyperandrogenism and PCOS, with related infertility (13). This evidence concerns the gene ALMS1 and obesity due to melanocortin 4 receptor deficiency.