In liver cancer, multiple different groups’ investigations showed that METTL14 inhibits EMT, invasion and metastasis of liver cancer cells by regulating m6A-modified target mRNAs such as EGFR/PI3K/AKT, DGCR8/primiR-126, USP48/SIRT6/glycolysis, CSAD, GOT2 and SOCS2. Here, USP48 is linked to liver cancer.