[171] Intriguingly, a recent report found that METTL3 deletion in macrophages significantly increases M1/M2-like tumor-associated macrophages and regulatory T cell infiltration into tumors, thus promoting tumorigenesis and metastasis, by inhibiting YTHDF1-mediated translation of SPRED2 and further enhancing the expression of TNF-α, IL-6 and ARG1. The gene discussed is METTL3; the disease is neoplasm.