Mettl3 deficiency results in the decreased infiltration and function of NK cells in tumor microenvironment thus promoting tumor growth and shorter survival time in mice by decreasing the protein expression of m6A-modifed SHP-2 mRNA, which leads to a suppressed activation of AKT and MAPK signaling pathway in NK cells (Fig. 4B). The gene discussed is PTPN11; the disease is neoplasm.