METTL3 and urinary bladder cancer: [102,221,222] METTL3 also plays oncogenic roles in bladder cancer by either promoting the expression of AFF4, IKBKB, RELA, MYC, or promoting YTHDF1/3-regulated translation of m6A-modified CDCP1 and ITGA6, or even by repressing the tumor suppressor genes such as SETD7 and KLF4.