For example, in colorectal cancer, METTL14 inhibits the proliferation, metastasis and invasion of tumor cells either by enhancing the expression of KLF4 in IGF2BP2-m6A manner, [260] or by inhibiting YTHDF2-mediated SOX472, or by suppressing XIST [261]. The gene discussed is IGF2BP2; the disease is colorectal cancer.