METTL3 and neoplasm: [258] Notably, m6A hypomethylation caused by METTL3 low expression leads to downregulation of PHLPP2 (negative AKT regulator) and upregulation of mTORC2 (negative AKT regulator) in more than 70 % of endometrial tumors, suggesting a tumor suppressive role of METTL3 (Fig. 5).