METTL3 and neoplasm: [170] Similarly, another paper also revealed that METTL3 deficiency inhibited the toll-like receptors (TLRs) signaling-mediated pro-inflammatory cytokines production and macrophage activation by increasing IRAKM mRNA (a negative regulator of TLRs) in an m6A manner, resulting in enhanced tumor growth and reduced TNF-α secretion (Fig. 4E).