METTL3 and cancer: [223–226] In addition, METTL3 has shown an elevated expression and oncogenic roles in many other cancers such as pancreatic cancer, glioblastoma, prostate cancer, breast cancer, osteosarcoma, oral squamous cell carcinoma, thyroid carcinoma, and head and neck squamous cell carcinoma by regulating different target genes in m6A-dependent manners (Fig. 5).