METTL14 and neoplasm: [176] Taken together, the role of METTL3/METTL14-mediated m6A in tumor microenvironment and progression has been shown consistent, however, the mechanisms such as polarization phenotype upon METTL3 deletion in macrophages, change of same signaling (NF-κB, TNF-α secretion, etc.)is not that consistent under different conditions or contexts.