PTPN2 and anaplastic large cell lymphoma: In contrast to PTPN2 depletion, TFRC knockout reduced mitoSOX levels (Figure 4D; Figure S4D, Supporting Information), decreased ROS production (Figure 4E; Figure S4E, Supporting Information), increased MMP (Figure 4F; Figure S4F, Supporting Information), and attenuated the accumulation of damaged mitochondria induced by CCCP treatment (Figure 4F; Figure S4F, Supporting Information) in ALK+ ALCL cells.