Functional assays revealed that TFRC knockout restored the decreased proliferation rate (Figure4A; Figure S4A, Supporting Information) and the increased apoptosis‐related protein (the cleaved forms of PARP) expression (Figure 4B; Figure S4B, Supporting Information) induced by PTPN2 knockout, indicating that PTPN2 promotes ALK+ ALCL progression by inhibiting TFRC. Here, TFRC is linked to anaplastic large cell lymphoma.