This does not conflict with the previous involvement of CDR1as in arrhythmogenesis through Nav1.5 and Kir6.2 but rather emphasizes the complexity and multiplicity of the roles of CDR1as in arrhythmias after MI, suggesting that different channels may be involved in different aspects or subsets of the arrhythmia phenotype. The gene discussed is SCN5A; the disease is myocardial infarction.