In an experimental model of brain insulin resistance (BIR)‐dependent cognitive impairment induced by insulin‐resistant NSCs, mice fed a high‐fat diet (HFD) showed reduced NSC proliferation and increased senescence of self‐renewing cells, as assessed by double‐labelling with BrdU and the immature neuron marker DCX (Natale et al. 2022). The gene discussed is INS; the disease is Insulin resistance.